عنوان

Chromosome aberrations /

1417564849

3805577672

9781417564842

9783805577670

b743305

Chromosome aberrations /

[Book]

editors, Günter Obe, Adyapalam T. Natarajan.

New York :

Karger,

©2004.

1 online resource (393, [1] pages) :

illustrations

Cytogenetic and genome research ;

v. 104, no. 1-4

"Single topic volume."

Papers presented at the 6th International Symposium on Chromosome Aberrations held at the University of Duisberg-Essen, Germany (10th to 13th September, 2003) and a collection invited papers are included.

Includes bibliographical references and index.

Pathways of DNA double-strand break repair and their impact on the prevention and formation of chromosomal aberrations / Pfeiffer P [and others] -- Mechanisms of DNA double strand break repair and chromosome aberration formation / Iliakis G [and others] -- The role of homologous recombination repair in the formation of chromosome aberrations / Griffin CS, Thacker J -- Recombination repair pathway in the maintenance of chromosomal integrity against DNA interstrand crosslinks / Sasaki MS [and others] -- Repair rates of R-band, G-band and C-band DNA in murine and human cultured cells / Sanders MH [and others] -- On the nature of visible chromosomal gaps and breaks / Savage JRK -- Molecular targets and mechanisms in formation of chromosomal aberrations : contributions of Soviet scientists / Belyaev I -- Progress towards understanding the nature of chromatid breakage / Bryant PE, Gray LJ, Peresse N -- Human-hamster hybrid cells used as models to investigate species-specific factors modulating the efficiency of repair of UV-induced DNA damage / Marcon F, Boei JJWA, Natarajan AT -- Mechanisms and consequences of methylating agent-induced SCEs and chromosomal aberrations : a long road traveled and still a far way to go / Kaina B -- Human fibroblasts expressing hTERT show remarkable karyotype stability even after exposure to ionizing radiation / Pirzio LM [and others] -- Mechanisms of formation of chromosomal aberrations : insights from studies with DNA repair-deficient cells / Palitti F -- In situ DNAse I sensitivity assay indicates DNA conformation differences between CHO cells and the radiation-sensitive CHO mutant IRS-20 / Maranon DG, Laudicina AO, Muhlmann M -- DNA damage processing and aberration formation in plants / Schubert I [and others] -- DNA and telomeres : beginnings and endings / Bailey SM, Goodwin EH -- DNA repair factors and telomere-chromosome integrity in mammalian cells / Hande MP -- Interstitial telomeric repeats are not preferentially involved in radiation-induced chromosome aberrations in human cells / Desmaze C [and others] -- Lack of spontaneous and radiation-induced chromosome breakage at interstitial telomeric sites in murine scid cells / Wong H-P [and others] -- Cytological indications of the complex subtelomeric structure / Drets ME -- Quantitative analysis of radiation-induced chromosome aberrations / Sachs RK [and others] -- Models of chromosome aberration induction : an example based on radiation track structure / Ballarini F, Ottolenghi A -- Virtual radiation biophysics : implications of nuclear structure / Kreth G, Finsterle J, Cremer C -- Dose dependency of FISH-detected translocations in stable and unstable cells after 137Cs[gamma] irradiation of human lymphocytes in vitro / Romm H, Stephan G -- Effect of DMSO on radiation-induced chromosome aberrations analysed by FISH / Cigarran S [and others] -- DNA damage in Chinese hamster cells repeatedly exposed to low doses of X-rays / Guerci AM, Dulout FN, Seoane AI -- Potassium bromate but not X-rays cause unexpectedly elevated levels of DNA breakage similar to those induced by ultraviolet light in Cockayne syndrome (CS-B) fibroblasts / Mosesso P [and others] -- Distribution of breakpoints induced by etoposide and X-rays along the CHO X chromosome / Martinez-Lopez W [and others] -- The repair of [gamma]-ray-induced chromosomal damage in human lymphocytes after exposure to extremely low frequency electromagnetic fields / Lloyd D [and others] -- Ionizing radiation-induced instant pairing of heterochromatin of homologous chromosomes in human cells / Abdel-Halim HI [and others] -- Cytogenetic damage in lymphocytes for the purpose of dose reconstruction : a review of three recent radiation accidents / Wojcik A [and others] -- Complex chromatid-isochromatid exchanges following irradiation with heavy ions? / Loucas BD [and others] -- G2 chromatid damage and repair kinetics in normal human fibroblast cells exposed to low- or high-LET radiation / Kawata T [and others] -- Cytogenetic effects of densely ionising radiation in human lymphocytes : impact of cell cycle delays / Nasonova E, Ritter S -- Chromosome aberrations induced by high-LET carbon ions in radiosensitive and radioresistant tumour cells / Virsik-Kopp P, Hofman-Huether H -- Induction of homologous recombination in the hprt gene of V79 Chinese hamster cells in response to low- and high-LET irradiation / Olsson G [and others] -- Cytogenetic analyses in peripheral lymphocytes of persons living in houses with increased levels of indoor radon concentrations / Oestreicher U, Braselmann H, Stephan G -- Effect of high-level natural radiation on chromosomes of residents in southern China / Hayata I [and others] -- Complex chromosomal rearrangements induced in vivo by heavy ions / Durante M [and others] -- Chromosome aberrations of clonal origin are present in astronauts' blood lymphocytes / George K [and others] -- Transgenerational transmission of radiation- and chemically induced tumors and congenital anomalies in mice : studies of their possible relationship to induced chromosomal and molecular changes / Nomura T [and others] -- Contribution of chromosomal imbalance to sperm selection and pre-implantation loss in translocationheterozygous Chinese hamsters / Sonta S -- Heritable translocations induced by dermal exposure of male mice to acrylamide / Adler I-D [and others] -- Chromosome banding in Amphibia. XXX. Karyotype aberrations in cultured fibroblast cells / Schmid M, Steinlein C, Haaf T -- Investigations into the biological relevance of in vitro clastogenic and aneugenic activity / Parry JM [and others] -- Region-specific chromatin decondensation and micronucleus formation induced by 5-azacytidine in human TIG-7 cells / Satoh T [and others] -- Micronuclei in lymphocytes of uranium miners of the former Wismut SDAG / Muller W-U, Kryscio A, Streffer C.

0

The role of chromosome aberrations in evolution and human health is well recognized. This volume brings together papers summarizing our current knowlege of the structure of interphase nuclei, chromosome structure, mechanisms of aberration formation and the practical application of this knowledge in radiobiology, biomonitoring of human populations and cancer research. Molecular cytogenetic techniques such as fluorescence in situ hybridization using whole chromosome and region specific painting DNA probes have been successfully used to identify and quantify chromosome aberrations, which is reflected in several papers of this volume. The mechanisms of chromosome aberration formation by different types of ionizing radiation are considered in detail. Furthermore, the important role of telomeres in maintaining chromosome integrity and their involvement in genomic instability are discussed. A final section is dedicated to the clinical relevance of chromosome aberrations in human hereditary diseases, e.g. Fanconi anemia or ataxia telangiectasia, and in many human cancers characterized by specific translocations or deletions. The study of chromosome aberrations is of great relevance in clinical genetics and oncology for diagnosis and disease prevention. Thus this publication is recommended reading for cytogeneticists, radiobiologists, oncologists, and post-graduate students of genetics and medicine.

Chromosome aberrations.

3805577672

Chromosome abnormalities, Congresses.

Chromosome abnormalities.

Chromosome abnormalities.

HEALTH & FITNESS-- Diseases-- Genetic.

MEDICAL-- Genetics.

HEA-- 039060

MED-- 107000

Natarajan, A. T.

Obe, G.

International Symposium on Chromosome Aberrations(6th :2003 :, Universität Duisburg)

20201204035018.0

pn

[Book]

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