عنوان

Periostin /

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Periostin /

[Book]

Akira Kudo, editor.

Singapore :

Springer,

2019.

1 online resource

Advances in experimental medicine and biology ;

1132

Intro; Preface; Contents; Part I: Overview of Periostin; 1: Naming, History, Future; References; Part II: Basic Properties of Periostin; 2: The Structure of the Periostin Gene, Its Transcriptional Control and Alternative Splicing, and Protein Expression; 2.1 The Gene Structure; 2.1.1 Mouse or Human Periostin Gene; 2.1.2 Alternative Splicing of the Mouse or Human Periostin Gene; 2.1.3 Other Vertebral Periostin Genes; 2.2 Transcription Control; 2.2.1 Transactivator and Cis-Element; 2.2.2 Factors Inducing Periostin Expression; 2.3 Protein

3.1 The EMI Domain of Periostin Is Responsible for Multimerization and Interacts with Extracellular Matrix Proteins3.2 The Tandem Repeat of Four FAS 1 Domains of Periostin Binds to Tenascin, BMP-1, and CCN3; 3.3 The CTD Possesses an Arg-Rich Region Responsible for Binding to Proteoglycans; 3.4 Conclusion; References; Part IV: Health and Disease in Organs; 4: Periostin Reexpression in Heart Disease Contributes to Cardiac Interstitial Remodeling by Supporting the Cardiac Myofibroblast Phenotype; 4.1 Introduction; 4.2 Periostin as a Regulator of Cardiac ECM

4.2.1 Previously Unrecognized Interstitium in the Vascular Adventitia -- A New Look at the Role for Periostin in Vascular Disease?4.2.2 Cardiac Regeneration and the Putative Role of Periostin; 4.2.3 Periostin as a Marker of Activated Myofibroblasts; 4.3 Heart Disease and Periostin -- Future Research and Treatment Modalities for Heart Failure; 4.3.1 Myocardial Infarction -- The Current Problem and Possible Research Directions; 4.3.2 Future Directions; 4.4 Synopsis; References; 5: Periostin in Bone Biology; 5.1 Expression of Periostin in Bone; 5.2 Abnormal Bone in Periostin Deficient Mice

5.3 Periostin in Collagen Cross-Linking5.4 Periostin in Mechanical Stress; 5.5 Periotin in Future; References; 6: Periostin in Bone Regeneration; 6.1 Introduction; 6.2 Bone Regeneration after Fracture; 6.3 Role of Periosteum in Bone Repair; 6.4 Periosteal Cells Express Periostin in Response to Bone Injury; 6.5 Periostin Is Required for Bone Repair; 6.6 Periostin Regulates the Skeletal Stem Cell Niche Within Periosteum; 6.7 Clinical Applications Using Periosteal Cells and Periostin in Bone Repair; References

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This book provides a comprehensive and up-to-date review of current understanding of periostin and its importance for human health and disease. Periostin is a secretory matricellular protein that has been revealed to play key roles in fibrillogenesis and cell migration, including metastasis of cancer cells. The production of periostin is upregulated during fibrotic responses and the mechanisms by which it promotes fibrosis have become a focus of interest owing to the potential clinical benefit to be derived from periostin blockade. In this book, readers will find coverage of all aspects, from the basic properties of periostin and its function as a scaffold for assembly of extracellular proteins through to its roles in bone and tissue regeneration, tumorigenesis, myocardial infarction, inflammatory and immune system disorders, and other diseases. Readers will also find the latest information on functions of periostin related to stemness and the application of periostin as a biomarker. It is hoped that the detailed knowledge of periostin and its pathobiological significance provided in this book will aid in the search for effective treatments for currently incurable diseases.

Springer Nature

com.springer.onix.9789811366574

9789811366567

9789811366581

9789811366598

Proteins-- Research.

Proteins-- Research.

SCIENCE-- Life Sciences-- Biochemistry.

MBGR

MBGR

PSD

SCI-- 007000

Kudo, Akira,1939-

20200823233203.0

pn

[Book]

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