Plasmonic Sensor using Double-layered Stimuli-responsive Polymer Microgel for Multiplexed Detection
General Material Designation
[Thesis]
First Statement of Responsibility
Mundel, Hannah Beverly Elizabeth
Subsequent Statement of Responsibility
Aitchison, James Stewart
.PUBLICATION, DISTRIBUTION, ETC
Name of Publisher, Distributor, etc.
University of Toronto (Canada)
Date of Publication, Distribution, etc.
2019
GENERAL NOTES
Text of Note
110 p.
DISSERTATION (THESIS) NOTE
Dissertation or thesis details and type of degree
M.A.S.
Body granting the degree
University of Toronto (Canada)
Text preceding or following the note
2019
SUMMARY OR ABSTRACT
Text of Note
Herein we present a sensor that uses surface plasmon resonance (SPR) and plasmonic waveguide resonance (PWR) modes to probe the behavior of two layers of stimuli-responsive polymers, called microgels, deposited on a gold film. These microgels can be molecularly imprinted, resulting in a high-loading-capacity synthetic receptor. In response to external stimuli, such as molecular binding events, their refractive index and thickness vary. Fabrication and testing demonstrated that changes in the SPR mode correspond to changes in the lower layer's refractive index and thickness with p-values below 0.03, whereas changes in the PWR mode correspond to changes in the upper layer's refractive index and thickness with p-values<0.02. The corresponding lowest limits of detection are 0.00073 RIU and 11 nm, and 0.0024 RIU and 41 nm, respectively. Furthermore, simulations indicate that good sensitivity to each layer is achievable, and that signal decoupling can be improved using TE PWR modes and Fabry-Perot resonances.