عنوان

The role of model integration in complex systems modelling :

(Number (ISBN

1280009284

(Number (ISBN

3642156029

(Number (ISBN

3642156037

(Number (ISBN

9781280009280

(Number (ISBN

9783642156021

(Number (ISBN

9783642156038

Erroneous ISBN

9783642156021

Number

b765094

Title Proper

The role of model integration in complex systems modelling :

General Material Designation

[Book]

Other Title Information

an example from cancer biology /

First Statement of Responsibility

Manish Patel, Sylvia Nagl.

Place of Publication, Distribution, etc.

London :

Name of Publisher, Distributor, etc.

Springer,

Date of Publication, Distribution, etc.

2010.

Specific Material Designation and Extent of Item

1 online resource (x, 168 pages) :

Other Physical Details

illustrations

Series Title

Understanding complex systems

Text of Note

Includes bibliographical references (pages 153-163) and index.

Text of Note

Nature to numbers: complex systems modelling of cancer -- Coping with complexity: modelling of complex systems -- Novel strategies for integrating models into systems-level simulations -- Experiments in model integration.

0

Text of Note

Model integration - the process by which different modelling efforts can be brought together to simulate the target system - is a core technology in the field of Systems Biology. In the work presented here model integration was addressed directly taking cancer systems as an example. An in-depth literature review was carried out to survey the model forms and types currently being utilised. This was used to formalise the main challenges that model integration poses, namely that of paradigm (the formalism on which a model is based), focus (the real-world system the model represents) and scale. A two-tier model integration strategy, including a knowledge-driven approach to address model semantics, was developed to tackle these challenges. In the first step a novel description of models at the level of behaviour, rather than the precise mathematical or computational basis of the model, is developed by distilling a set of abstract classes and properties. These can accurately describe model behaviour and hence describe focus in a way that can be integrated with behavioural descriptions of other models. In the second step this behaviour is decomposed into an agent-based system by translating the models into local interaction rules. The book provides a detailed and highly integrated presentation of the method, encompassing both its novel theoretical and practical aspects, which will enable the reader to practically apply it to their model integration needs in academic research and professional settings. The text is self-supporting. It also includes an in-depth current bibliography to relevant research papers and literature. The review of the current state of the art in tumour modelling provides added value.

Source for Acquisition/Subscription Address

Springer

Stock Number

978-3-642-15602-1

Title

Role of model integration in complex systems modelling.

International Standard Book Number

9783642156021

Cancer-- Mathematical models.

Cancer-- Research-- Methodology.

Models, Theoretical.

Neoplasms.

Research Design.

Biologisches System

Cancer-- Mathematical models.

Komplexes System

Krebs

Mathematisches Modell

Physique.

GPFC.

TEC000000.

Number

Edition

Class number

Book number

Class number

Class number

Patel, Manish I.

Nagl, Sylvia.

Date of Transaction

20201206104307.0

Cataloguing Rules (Descriptive Conventions))

pn

Electronic name

[Book]

Y