عنوان

Accelerated path to cures /

(Number (ISBN

3030103390

(Number (ISBN

3319732382

(Number (ISBN

3319732390

(Number (ISBN

9783030103392

(Number (ISBN

9783319732381

(Number (ISBN

9783319732398

Erroneous ISBN

3319732374

Erroneous ISBN

9783319732374

Title Proper

Accelerated path to cures /

General Material Designation

[Book]

First Statement of Responsibility

Josep Bassaganya-Riera, editor.

Place of Publication, Distribution, etc.

Cham, Switzerland :

Name of Publisher, Distributor, etc.

Springer,

Date of Publication, Distribution, etc.

[2018]

Specific Material Designation and Extent of Item

1 online resource :

Other Physical Details

illustrations

Text of Note

Includes bibliographical references and index.

Text of Note

Intro; Contents; Contributors; Chapter 1: Introduction to Accelerated Path to Cures and Precision Medicine in Inflammatory Bowel Disease; Overview; LANCL2 Drug Development Use Case; Network Modeling for PD Biomarker Analyses Use Case; References; Chapter 2: Computer-Aided Drug Discovery; Overview; Structure-Based Versus Ligand-Based Modeling; Ligand-Based Modeling Approaches; Similarity Searching; Ligand-Based Pharmacophore Modeling; Quantitative-Structure Activity Relationship Modeling (QSAR); Structure-Based Modeling Approaches; Molecular Docking; Structure-Based Pharmacophore Modeling.

Text of Note

Accelerating the Path to Precision MedicineComputational Models Used for Precision Medicine Discovery Measures Endpoints of Immune Mediated and Inflammatory Diseases; Concluding Remarks; References; Chapter 5: Development of Synthetic Patient Populations and In Silico Clinical Trials; Overview; Clinical Research and Clinical Trials; Design Strategies; Data Sources; Predictive Modeling for Precision Medicine; Data-Driven Models; Mechanistic Models; Rule-Based Models; Human Avatars: Virtual Patient Populations; Treatment Design; Data-Driven Design; Mechanistic Modeling-Based Design.

Text of Note

Citrobacter rodentium Infection Model of ColitisMDR1a−/− Model of Colitis; Pig as Model of Colitis; Cell-Specific Knockout Mice; Animal Models Used in Drug Development for IBD; Utilization of Computational Models in Preclinical Studies; Concluding Remarks; References; Chapter 4: From Nutritional Immunology to Drug Development; Overview; Nutritional Modulation of Immune-Mediated Diseases; Important Immunometabolic Pathways; Nutrition-Based Therapeutics Used to Treat Gastrointestinal Diseases; Computational Approaches to Discover New Therapeutics: A Precision Medicine Initiative

Text of Note

Molecular Docking and Virtual ScreeningMolecular Docking; Virtual Screening; Application of Molecular Dynamics Simulations in Drug Discovery; General Considerations; Applications of Molecular Dynamics in Generating Conformational Ensembles; MD and Scoring; MD to Discover Novel Binding Sites; Success Stories in Computational Drug Discovery; Concluding Remarks; References; Chapter 3: Preclinical Studies: Efficacy and Safety; Preclinical Studies: Safety; Preclinical Studies: Efficacy; Animal Models of IBD to Test Therapeutic Efficacy; DSS-Induced Colitis; Adoptive Transfer Model of Colitis.

Text of Note

Statistical AnalysisDimensionality Reduction; Analysis of Variance; Concluding Remarks; References; Index.

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8

8

8

8

Text of Note

Accelerated Path to Cures provides a transformative perspective on the power of combining advanced computational technologies, modeling, bioinformatics and machine learning approaches with nonclinical and clinical experimentation to accelerate drug development. This book discusses the application of advanced modeling technologies, from target identification and validation to nonclinical studies in animals to Phase 1-3 human clinical trials and post-approval monitoring, as alternative models of drug development. As a case of successful integration of computational modeling and drug development, we discuss the development of oral small molecule therapeutics for inflammatory bowel disease, from the application of docking studies to screening new chemical entities to the development of next-generation in silico human clinical trials from large-scale clinical data. Additionally, this book illustrates how modeling techniques, machine learning, and informatics can be utilized effectively at each stage of drug development to advance the progress towards predictive, preventive, personalized, precision medicine, and thus provide a successful framework for Path to Cures.

Source for Acquisition/Subscription Address

Springer Nature

Stock Number

com.springer.onix.9783319732381

Title

Accelerated path to cures.

International Standard Book Number

9783319732374

Drug development.

Immunoinformatics.

Immunology.

Biology, life sciences.

Drug development.

HEALTH & FITNESS-- Diseases-- General.

Health & safety aspects of IT.

Immunoinformatics.

Immunology.

Immunology.

Life sciences: general issues.

MEDICAL-- Clinical Medicine.

MEDICAL-- Diseases.

MEDICAL-- Evidence-Based Medicine.

MEDICAL-- Internal Medicine.

HEA-- 039000

MED-- 014000

MED-- 022000

MED-- 045000

MED-- 112000

MJCM

MJCM

Number

Edition

Class number

Bassaganya-Riera, Josep

Date of Transaction

20200823104105.0

Cataloguing Rules (Descriptive Conventions))

pn

Electronic name

[Book]

Y