عنوان

Advances in statistical bioinformatics :

(Number (ISBN

1107027527 (hardback)

(Number (ISBN

9781107027527 (hardback)

Number

dltt

Title Proper

Advances in statistical bioinformatics :

General Material Designation

[Book]

Other Title Information

models and integrative inference for high-throughput data /

First Statement of Responsibility

edited by Kim-Anh Do, The University of Texas M.D. Anderson Cancer Center, Zhaohui Steven Qin, Emory University, Atlanta, GA, Marina Vannucci, Rice University, Houston, TX

Specific Material Designation and Extent of Item

xv, 481 pages, 16 unnumbered pages of plates :

Other Physical Details

illustrations (some color) ;

Dimensions

24 cm

Text of Note

Includes bibliographical references and index

Text of Note

"When Sanger and Coulson first described a reliable, efficient method for DNA sequencing in 1975 (Sanger and Coulson, 1975), they made possible the full sequencing of both genes and entire genomes. Although the method was resource-intensive, many institutions invested in the necessary equipment, and Sanger sequencing remained the standard for the next 30 years. Refinement of the process increased read lengths from around 25 to 2 Mohlere, Wang, and Manyam almost 750 base pairs (Schadt et al., 2010, fig. 1). While this greatly increased efficiency and reliability, the Sanger method still required not only large equipment but significant human investment, as the process requires the work of several people. This prompted researchers and companies such as Applied Biosystems to seek improved sequencing techniques and instruments. Starting in the late 2000s, new instruments came on the market that, although they actually decreased read length, lessened run time and could be operated more easily with fewer human resources (Schadt et al., 2010). Despite discoveries that have illuminated new therapeutic targets, clarified the role of specific mutations in clinical response, and yielded new methods for diagnosis and predicting prognosis (Chin et al., 2011), the initial promise of genomic data has largely remained so far unfulfilled. The difficulties are numerous"--

Bioinformatics-- Statistical methods

Biometry

Genetics-- Technique

Number

Edition

Class number

Book number

Do, Kim-Anh,1960-

Qin, Steven,1972-

Vannucci, Marina,1966-

Date of Transaction

20141128225518.0

Cataloguing Rules (Descriptive Conventions))

rda

Electronic name

[Book]

Y