• Home
  • Advanced Search
  • Directory of Libraries
  • About lib.ir
  • Contact Us
  • History

عنوان
Non-coding Rnas in complex diseases: a bioinformatics perspective

پدید آورنده
/ edited by Xia Li... [et al.].

موضوع
Non-coding RNA.,Genetic disorders.,Human Genetics.,Bioinformatics.,Bioinformatics.

رده

کتابخانه
Central library and document university of Kurdistan

محل استقرار
استان: Kurdistan ـ شهر: Sanandaj

Central library and document university of Kurdistan

تماس با کتابخانه : 9-08733624006 و 08733664600

INTERNATIONAL STANDARD BOOK NUMBER

(Number (ISBN
978-981-13-0718-8
(Number (ISBN
978-981-13-0719-5 (eBook)

NATIONAL BIBLIOGRAPHY NUMBER

Country Code
IR
Number
6402

LANGUAGE OF THE ITEM

.Language of Text, Soundtrack etc
انگلیسی

COUNTRY OF PUBLICATION OR PRODUCTlON

Country of publication
IR

TITLE AND STATEMENT OF RESPONSIBILITY

Title Proper
Non-coding Rnas in complex diseases: a bioinformatics perspective
General Material Designation
[electronic resources]
First Statement of Responsibility
/ edited by Xia Li... [et al.].

.PUBLICATION, DISTRIBUTION, ETC

Place of Publication, Distribution, etc.
Singapore
Name of Publisher, Distributor, etc.
: Springer Nature
Date of Publication, Distribution, etc.
, 2018.

PHYSICAL DESCRIPTION

Specific Material Designation and Extent of Item
x, 126 pages
Other Physical Details
: illustrations (chiefly color), tables.

SERIES

Series Title
Advances in experimental medicine and biology, v. 1094.

GENERAL NOTES

Text of Note
Editors: Xia Li, Juan Xu, Yun Xiao, Shangwei Ning, Yunpeng Zhang.

INTERNAL BIBLIOGRAPHIES/INDEXES NOTE

Text of Note
Includes bibliographical references.

CONTENTS NOTE

Text of Note
Intro; Preface; Contents; Contributors; Chapter 1: Non-coding RNA Resources; 1.1 Introduction; 1.2 ncRNA Annotation Resources; 1.2.1 miRBase; 1.2.2 NONCODE; 1.2.3 LNCipedia; 1.2.4 LNCat; 1.3 ncRNA-Associated Disease Resources; 1.3.1 HMDD; 1.3.2 miR2Disease; 1.3.3 LncRNADisease; 1.3.4 Lnc2Cancer; 1.4 ncRNA-Related Variants Resources; 1.4.1 dPORE-miRNA; 1.4.2 miRdSNP; 1.4.3 miRNASNP; 1.4.4 MirSNP; 1.4.5 PolymiRTS; 1.4.6 MicroSNiPer; 1.4.7 lncRNASNP; 1.4.8 LincSNP; 1.5 Other ncRNA Resources; 1.5.1 DIANA-LncBase; 1.5.2 ChIPBase; 1.5.3 LncRNA2Target; 1.6 Perspectives and Conclusion; References Chapter 2: Systematic Identification of Non-coding RNAs2.1 Introduction; 2.2 Methods; 2.2.1 Identification of miRNAs; 2.2.2 Identification of lncRNAs; 2.3 Results; 2.3.1 miRNA Transcriptome Detected by Small RNA-seq Annotation; 2.3.2 Re-annotation of Microarray for Revealing lncRNAs; 2.3.3 Summaries of lncRNA Annotation Resources; 2.3.4 Construction of miRNA and lncRNA Expression Profiles in Heart Failure (Based on miRNA-seq and RNA-seq); 2.4 Concluding Remarks; References; Chapter 3: Functional Characterization of Non-coding RNAs Through Genomic Data Fusion; 3.1 Introduction; 3.2 Methods 3.2.1 MiRNA Expression Data Sets3.2.2 Identification of Orthologous miRNAs; 3.2.3 Construction of a Conserved miRNA Co-expression Network; 3.2.4 MiRNA Genomic Location, Cluster, Family, TF, Targets and Disease Information; 3.2.5 Gene Expression Data from miRNA Knockout/Transfection Experiments; 3.2.6 Functional Enrichment Analysis; 3.3 Results; 3.3.1 Construction of a Conserved miRNA Co-expression Network; 3.3.2 Functional Relationships Between Conserved Co-expressed miRNA Pairs; 3.3.3 Dysfunction of miRNA Cooperation in Disease; 3.4 Concluding Remarks; References Chapter 4: Genomic-Scale Prioritization of Disease-Related Non-coding RNAs4.1 Introduction; 4.2 Expression-Based Technologies; 4.3 Biological Network-Based Technologies; 4.4 Known Disease-ncRNA Association-Based Technologies; 4.5 Integrated Strategy Based Technologies; 4.6 Conclusions; References; Chapter 5: Genome-Wide Mapping of SNPs in Non-coding RNAs; 5.1 Introduction; 5.2 Mapping SNPs in Human miRNA Targets; 5.3 Mapping Disease-Associated SNPs in lncRNAs; 5.4 Identification of SNPs ́Effects on lncRNA Structure; 5.5 Mapping Disease-Associated SNPs in lncRNA TFBSs 5.6 Perspectives and ConclusionReferences; 6: Profiling DNA Methylation Patterns of Non-coding RNAs (ncRNAs) in Human Disease; 6.1 Introduction; 6.2 Re-annotation of Data from the Infinium 450 k Array to Construct lncRNA Methylation Profiles; 6.2.1 Probe Mapping; 6.2.2 DNA Methylation Level Evaluating; 6.2.3 LncRNAs Methylation Profiles Constructing and Methylation Pattern Detecting; 6.3 Classifying lncRNA Methylation Patterns in Cancers; 6.3.1 A Strategy for Methylation Pattern Classifying; 6.3.2 Analysis of Repetitive Elements at lncRNA Promoters.
0

SUMMARY OR ABSTRACT

Text of Note
This book offers an in-depth and comprehensive review on current understanding of regulatory ncRNAs in complex diseases from a view of bioinformatics. It conveys state-of-the-art bioinformatics tools and methods for ncRNAs from computational detection, functional prediction, to their roles in diseases. Computational methods used to investigate uncharacterised ncRNAs in diseases are mainly summarized in seven aspects: DNA variation of ncRNAs in diseases, prioritization of disease-related ncRNAs, dysregulation epigenetic factors that regulate ncRNA misexpression (DNA methylation and histone-modification), complex crosstalk across ncRNAs, ncRNAs acted as competing regulators to mediate the expression of protein-coding genes, non-coding RNAs mediated risk pathways,and their contributions to drug target predictions. The generally used data resources of ncRNAs are also listed in the end. This book provides important information on the current progress in the fast-moving fields of bioinformatics for regulatory ncRNAs. It provides a timely and useful reference for computational biologists, specifically with RNA interests, and other related areas.Prof. Xia Li is a Professor and the Dean of College of Bioinformatics Science and Technology, Harbin Medical University, China. Dr. Yun Xiao, Dr. Juan Xu, Dr. Shangwei Ning and Dr. Yunpeng Zhang are from College of Bioinformatics Science and Technology, Harbin Medical University, China.

TOPICAL NAME USED AS SUBJECT

Entry Element
Non-coding RNA.
Entry Element
Genetic disorders.
Entry Element
Human Genetics.
Entry Element
Bioinformatics.

UNCONTROLLED SUBJECT TERMS

Subject Term
Bioinformatics.

PERSONAL NAME - SECONDARY RESPONSIBILITY

Relator Code
Editor
Li, Xia,

ORIGINATING SOURCE

Country
ایران
Agency
Central Library of the University of Kurdistan
Date of Transaction
20200209

old catalog

e

BL
280328
1

a
Y

Proposal/Bug Report

Warning! Enter The Information Carefully
Send Cancel
This website is managed by Dar Al-Hadith Scientific-Cultural Institute and Computer Research Center of Islamic Sciences (also known as Noor)
Libraries are responsible for the validity of information, and the spiritual rights of information are reserved for them
Best Searcher - The 5th Digital Media Festival